Fri Jan 06 2023

33 articles - From Friday Dec 30 2022 to Friday Jan 06 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Arthritis Care Res (Hoboken)

2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases.

Application of these recommendations should consider patients' individual risk for vaccine-preventable illness and for disease flares, particularly if immunosuppressive medications are held for vaccination. Shared decision-making with patients is encouraged in clinical settings.

Pubmed   Journal   ReadQx 

Arthritis Rheumatol

2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases.

Application of these recommendations should consider patients' individual risk for vaccine-preventable illness and for disease flares, particularly if immunosuppressive medications are held for vaccination. Shared decision-making with patients is encouraged in clinical settings.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Rheum Dis

Alterations in the cutaneous microbiome of patients with psoriasis and psoriatic arthritis reveal similarities between non-lesional and lesional skin.

These findings show differences in diversity, bacterial composition and microbe-microbe interactions between healthy and psoriatic skin, both L and NL. We further identified bacterial biomarkers that differentiate disease phenotypes, which could potentially aid in predicting the transition from PsO to PsA.

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Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis.

Chemerin seems an interesting surrogate biomarker for PVR in SSc-PAH. Increased chemerin serum levels and CMKLR1 expression by PA-SMCs may contribute to SSc-PAH pathogenesis by inducing PA-SMC proliferation.

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Long-term effectiveness and persistence of ustekinumab and TNF inhibitors in patients with psoriatic arthritis: final 3-year results from the PsABio real-world study.

At 3 years, there was generally comparable persistence after ustekinumab or TNFi treatment, but AE rates were lower with ustekinumab.

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Malignancy risk with tofacitinib versus TNF inhibitors in rheumatoid arthritis: results from the open-label, randomised controlled ORAL Surveillance trial.

Risk of malignancies was increased with tofacitinib versus TNFi, and incidence was highest in patients with HxASCVD or increasing cardiovascular risk. This may be due to shared risk factors for cardiovascular risk and cancer.

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Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking.

Occupational inhalable agents could act as important environmental triggers in RA development and interact with smoking and RA-risk genes leading to excessive risk for ACPA-positive RA. Future studies are warranted to assess preventive strategies aimed at reducing occupational hazards and smoking, especially among those who are genetically vulnerable.

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Syntenin-1-mediated arthritogenicity is advanced by reprogramming RA metabolic macrophages and Th1 cells.

The syntenin-1/SDC-1 pathway plays a critical role in the inflammatory and metabolic landscape of RA through glycolytic MF and Th1 cell cross-regulation (graphical abstract).

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The provisional OMERACT ultrasonography score for giant cell arteritis.

We developed a provisional OGUS for potential use in clinical trials.

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Arthritis Care Res (Hoboken)

Changes in tophus composition during urate-lowering therapy: a dual energy CT study.

The composition of the tophus is dynamic and changes during urate-lowering therapy for gout management. The soft tissue component of the tophus is slower to respond and may persist without measurable MSU crystal deposition.

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Mind the Mood: Momentary Depression and Anxiety Moderate the Correspondence between Subjective and Objective Cognitive Functioning in Fibromyalgia.

Individuals with FM may be more accurate in their self-perception of momentary changes in mental processing speed during periods of less pronounced mood symptoms based on their corresponding objective processing speed performance. However, during moments of heightened depression and anxiety, we found increasingly less correspondence between SCD and objective performance, suggesting psychological symptoms may play an important role in self-perception of cognitive dysfunction in FM as it relates to mental processing speed.

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Why don't some people with knee osteoarthritis improve with exercise? A qualitative study of responders and non-responders.

Responders and non-responders shared some similar perceptions of exercise. However, along with perceived limitations in trial outcome measurements, non-responders encountered challenges with excess weight, comorbidities, stressors and life events which led to sub-optimal adherence, and collectively were perceived to contribute to non-response.

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Arthritis Res Ther

Axl regulated survival/proliferation network and its therapeutic intervention in mouse models of glomerulonephritis.

Results from this study emphasize the important role of Axl signaling in LN and highlight Axl as an attractive target in LN.

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Clinical and serological association of plasma 25-hydroxyvitamin D (25(OH)D) levels in lupus and the short-term effects of oral vitamin D supplementation.

Vitamin D deficiency is common in SLE. Geographical location of residence is the major determinant rather than the disease activity. The IFN regulated proteins reflect disease activity independent of vitamin D levels. High-dose oral vitamin D supplementation seems safe and more effective in improving vitamin D levels in SLE.

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Distinct gene signatures of monocytes and B cells in patients with giant cell arteritis: a longitudinal transcriptome analysis.

Gene signatures of monocyte activation and B cell inactivation were characteristic of GCA and associated with treatment response.

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Early removal of the infrapatellar fat pad/synovium complex beneficially alters the pathogenesis of moderate stage idiopathic knee osteoarthritis in male Dunkin Hartley guinea pigs.

/conclusion Formation of the FCT resulted in reduced OA-associated changes in both bone and cartilage. This benefit may be associated with a decrease in inflammatory mediators at transcript and protein levels; and/or improved biomechanical properties. Thus, the IFP/SC may play a role in the pathogenesis of knee OA in this strain, with removal prior to disease onset appearing to have short-term benefits.

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Quantification of pre-existing radiographic damage and its relationship with joint activity and long-term clinical outcomes with secukinumab therapy in patients with psoriatic arthritis.

PsA patients showed substantial prevalence of RD at baseline that correlated with time since diagnosis, but patient's individual joint activity was strongly associated with pre-existing RD at those joints. Patients with the highest RD at baseline had a reduced likelihood of achieving zero joint count status.

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Arthritis Rheumatol

Anti-mitochondrial antibodies predict erosive disease development in rheumatoid arthritis.

Our findings demonstrate the presence of novel autoantibodies targeting mitochondria in RA. AMAs stratified patients based on disease phenotype and predicted development of erosive disease, including in patients with seronegative disease. Our results highlight the essential role of mitochondria in RA pathogenesis and suggest a possible benefit of therapies targeting mitochondrial-mediated inflammation and clearance in these patients.

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Genome-wide imputation identifies novel associations and localises signals in idiopathic inflammatory myopathies.

We report novel and strong associations in IIM and PM, and localise signals to single genes and immune cell types.

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Rheumatology (Oxford)

Artificial Intelligence in osteoarthritis: repair by knee joint distraction shows association of pain, radiographic and immunologic outcomes.

Automatic radiographic measurements show improved joint structure in most patients after KJD in regular care. MAC JSW increased significantly and was associated with SF biomarker level changes and even with improvements in pain as experienced by these patients.

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Genetics of SLE: does this explain susceptibility and severity across racial groups?

Additionally, the effectiveness of some of the drugs used in SLE has been found to vary across ancestries, which might affect the progression of the disease, but it is unclear whether these differences are pharmacogenetic. We concluded that to understand the full role of genetics in the risk, presentation and response to treatment of SLE, larger studies including individuals from a wider representation of ancestries will be required.

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Janus kinase inhibitors alter NK cells phenotype and inhibit their antitumor capacity.

JAKi have a phenotypic and functional impact on NK cells activation and impair their antitumor activity with a variable impact depending on the JAKi. It remains an open question whether this mechanism can explain the increased tumor risk observed with TOFA.

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Risk factors for haemodynamic compromise in multisystem inflammatory syndrome in children-a multicentre retrospective study.

Key clinical and laboratory parameters of MIS-C were identified as risk factors for severe disease, predominantly during the disease course and not at the time of admission; and may prompt close monitoring, and earlier, more aggressive treatment decisions. Patients presenting with a Kawasaki-like phenotype were less likely to require inotropic support.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Rheum Dis

Greetings from the editor 2023.

Pubmed   Journal   ReadQx 

Occupational inhalants, genetics and the respiratory mucosal paradigm for ACPA-positive rheumatoid arthritis.

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Site of invasion revisited: epigenetic drivers of joint destruction in RA.

While their active role in the invasion of RA synovium into cartilage has long been studied, recent studies have brought new aspects of their heterogeneity and propagation in RA. This review integrates old and new evidence to give an overview picture of the processes active at the sites of invasive synovial tissue growth in RA.

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Towards molecular-pathology informed clinical trials in childhood arthritis to achieve precision medicine in juvenile idiopathic arthritis.

A further consequence of recent progress is a reducing pool of available children or young people who are eligible for new trials. In this review we consider how progress towards a molecular based approach to defining treatment targets and informing trial design in JIA, combined with novel approaches to clinical trials, could provide strategies to maximise discovery and progress, in order to move towards precision medicine for children with arthritis.

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Arthritis Res Ther

The role of the sirtuin family in cartilage and osteoarthritis: molecular mechanisms and therapeutic targets.

However, the molecular mechanism of the SIRT family against the onset and development of OA remains poorly elucidated. In this review, we will discuss the potential protective role of SIRT in the progression of OA and summarize several sirtuin-activating molecules as well as their potential therapeutic applications for OA.

Pubmed   Journal   ReadQx   PMC

Arthritis Rheumatol

The Biology of Pain - Through the Rheumatology Lens.

Recent advances in neurobiological knowledge have highlighted the importance of nociplastic pain mechanisms. In this review we aim to explore the biology of pain with a particular focus on nociplastic pain and RA.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Rheum Dis

Genetically proxied TYK2 inhibition is associated with reduced sarcoidosis susceptibility.

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Two cases with new onset of ANCA-positive eosinophilic granulomatosis with polyangiitis under treatment with dupilumab: coincidence or causality?

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Rheumatology (Oxford)

Osteonecrosis in patients with juvenile dermatomyositis: is it associated with anti-MDA5 autoantibody?

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Letters&Replies

Letters to the editors and authors’ replies

Arthritis Res Ther

Response letter to "Latent class analysis of 216 patients with adult-onset Still's disease" by Sugiyama et al.

In 2022, VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome, an established X-linked disease associated with a somatic mutation in UBA1, is considered as a differential diagnosis for AOSD particularly in elderly. These patients from Class 2 could benefit from more explorations for mild myelodysplasia and VEXAS.

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